What’s your variant?

So, the great thing about Lagree, which Sebastien talks about a lot is that it strengthens and tones, but also provides a cardiovascular workout.

The way this works is that through Time Under Tension training, your slow twitch muscle fibers, which are the ones primarily responsible for endurance based training, such as Lagree, are active. Your slow twitch muscle fibers have a high concentration of mitochondria, which you may recall from high school biology are the powerhouse of the cell. Mitochondria rely on oxygen to break down carbs and fat for energy. The more mitochondria you have, the better you are at resisting fatigue through exercise and the best way to cue your body to generate more mitochondria, is, you guessed it, to exercise more.

There is a certain gene, called PPARGC1A, henceforth referred to as The Lagree Gene is the one responsible for creating new mitochondria. This is the same pathway is activated through time under tension and cardiovascular training, so, doing Lagree does double duty, not only is it building up your your muscle endurance, slow twitch muscle fibers, and even converting some of your fast twitch muscle fibers into slow twitch but also improving your VO2 max! Which is why Lagree is a great way to both train your muscles and your cardiovascular health.

Everyone has this gene and the capacity to make new mitochondria, but the genotype, or variation of the genetic code that you have at this genetic locus, affects its expression. For some, they have a variation that results in increased expression of this gene, especially in response to endurance training. For these people its easier to get the cardiovascular benefits of Lagree. For some people, who have the standard variant of this gene, it is harder to generate new mitochondria in response to endurance training. Which doesn't mean they shouldn't do Lagree, everyone should do Lagree! But for some, they may need to do Lagree as well as program in more cardio such as versa climbing, HIIT, or power lifting to get the full activation of the Lagree gene and including Lagree will actually help them in performance of these other activities! (There is evidence that rather than switching the muscle type it enhances metabolic efficiency of fast-twitch muscle fibers (Varillas-Delgado).

What’s included?

• Cheek-swab kit + concise report including training type, response rate, dietary, and recovery insights

• Results in 4-6 weeks after sample arrives at the lab.

• Lagree Gene Variant and other Fitness Genes report with personalized training program overview.

• $50 credit if you upgrade to DNA Perfomance Blueprint or GNR8 Transformation within 30 days of purchase.

Learn Your Levers

• Cheek-swab kit + concise report including training type, response rate, dietary, and recovery insights

• Results in 4-6 weeks after sample arrives at the lab.

• $50 credit if you upgrade to DNA Perfomance Blueprint or GNR8 Transformation within 30 days of purchase.